IMPIANTI DENTALI KEYSTONE




GENESIS - Building a Biomimetic Surface


The BioSpark™ process results in a hydrophilic implant surface that mimics the chemical composition and structure of natural bone.

CREATING MACRO-MICRO SURFACE ROUGHNESS.

• The body of the implant is roughened and double-etched creating the macro-micro surface


KEYSTONE DENTAL IMPLANTS IN CROATIA

ANODIZATION – THE ANATITE™ PROCESS

• Genesis implants are anodized through an electrochemical process to generate the natural titanium oxide surface, turning the implant to a uniform pink color



THE BIOSPARK™ PROCESS

• The Anodic Spark Deposition (ASD*) process creates controlled ‘sparking’ to produce a uniform nano roughened surface, enriched with charged calcium and phosphorous ions



THE RESULT— GENESIS THE BIOMIMETIC IMPLANT SYSTEM™

A surface composition that offers:

• A macro-micro-nano texture similar to that of natural bone

• A moderately roughened pink collar to maximize bone levels** and enhance aesthetic outcomes



* Also known as microarc oxidation and glow discharge deposition
** Zetterqvist L. et al. A Prospective, Multicenter, Randomized-controlled 5 year study of Hybrid and Fully-Etched Implants for incidence of Peri-implantitis. J Periodontology 2009 Dec 23 (14pp.).



The BioSpark™ surface contains a unique combination of properties that mimic the chemical composition and structure of natural bone


The hydrophilic surface of Genesis attracts blood to the site. This helps stimulate angiogenesis— a critical factor for endosseous healing—which provides vital nutrients and growth factors to the healing implant site.



During healing, fibronectin attracts and promotes binding of osteoblasts. The preferential absorption of fibronectin on the BioSpark™ surface may account for the enhanced adhesion, proliferation and metabolic activity of osteoblasts.1



Compared to traditional macro-rough surfaces, the Genesis macro-micro-nano increases osteoblast adhesion.



Compared to traditional macro-rough surfaces, the Genesis macro-micro-nano increases osteoblast adhesion.



Charged calcium and phosphorous ions in the Genesis nanotexture* fuel osteoblast activity. P ions stimulate osteoblasts triggering bone formation while Ca ions promote bone mineralization.



The nanostructure surrounding the charged ions forms a micromechanical bond between the newly formed bone and the implant.

*See Genesis Building a Biomimetic Surface Insert bone blood fibronectin osteoblasts bone
**Sandrini E, Morris C, Chiesa R, Cigada A, Santin M. In vitro assessment of the osteointegrative potential of a novel multiphase anodic spark deposition coating for orthopaedic and dental implants. J Biomed Mater Res Part B: Appl Biomater 73B; 2005; 392-399

GENESIS - Selected Papers on the Biomimetic Surface


Surface


• One-Step Oral Rehabilitation by Means of Implants’ Insertion, Le Fort 1, Grafts, and Immediate Loading. Journal of Craniofacial Surgery, Nov 2009/ Vol. 20 / No. 6/pp 1-6

• Giavaresi G, Chiesa R, Fini M, Sandrini E. Effect of a Multiphasic Anodic Spark Deposition Coating on the Improvement of Implant Osseoiintegration in the Osteopenic Trabecular Bone of Sheep. The Int’l Jrnl of Oral & Maxillofacial Implants 23(4); 2008; 659-668

• Chiesa R, Giavaresi G, Fini M, Sandrini E, Giordano C, Bianchi A, Giardino R. In vitro and in vivo performance of a novel surface treatment to enhance osseointegration of endosseous implants. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103; 2007; 745-56

• Sandrini E, Giordano C, Busini V, Signorelli E, Cigada A. Apatite formation and cellular response of a novel bioactive Titanium. Journal of Materials Science: Materials in Medicine 18; 2007; 1225–1237

• LeGuehennec L, Soueidan A, Layrolle P, Amouriq Y. Surface treatments of titanium dental implants for rapid osseointegration. Dental Materials 23; 2007; 844-854

• Giordano C, Sandrini E, Busini V, Chiesa R, Fumagalli G, Giavaresi G, Fini M. A new chemical etching process to improve endosseous implant osseointegration: In vitro evaluation on human osteoblast-like cells. The International Journal of Artificial Organs 29(8); 2006; 772-780

• Sandrini E, Morris C, Chiesa R, Cigada A, Santin M. In Vitro Assessment of the Osteointegrative Potential of a Novel Multiphase Anodic Spark Deposition Coating for Orthopaedic and Dental Implants. Journal of Biomedical Materials Research Part B, Applied Biomaterials 2005; May; 73:2:392-399

• Giordano C, Chiesa R, Sandrini E, Cigada A, Giavaresi G, Fini M, Giardino R. Physical and biological characterizations of a novel multiphase anodic spark deposition coating to enhance implant osseointegration. Journal of Materials Science: Materials in Medicine 2005; 16:1221-1229

• Yang B, Uchida M, Kim H, Zhang X, Kokubo T. Preparation of bioactive titanium metal via anodic oxidation treatment. Biomaterials 2004; 25:1003-1010

• Giordano C, Sandrini E, Del Curto B, Signorelli E, Rondelli G, Di Silvio L. Titanium for osteointegration: Comparison between a novel biomimetic treatment and commercially exploited surfaces. Journal of Applied Biomaterials & Biomechanics 2004; 2:35-44

• Chiesa R, Sandrini E, Santin M, Rondelli G, Ciga A. Osteointegration of titanium and its alloys by anodic spark deposition and other electrochemical techniques: A review. Journal of Applied Biomaterials & Biomechanics 1; 2003; 91-107

• Sandrini E, Chiesa R, Rondelli G, Santin M, Cigada A. A novel biomimetic treatment for an improved osteointegration of titanium. Journal of Applied Biomaterials & Biomechanics 1; 2003; 33-42

Aesthetics


• Park SE, DaSilva JD, Weber HP, Ishikawa-Nagai N. Optical phenomenon of peri-implant soft tissue. Part I. Spectrophotometric assessment of natural tooth gingival and peri-implant mucosa. Clin. Oral Impl. Res.18; 2007; 569-574

• Ishikawa-Nagai S, DaSilva JD, Weber HP, Park SE. Optical phenomenon of peri-implant soft tissue. Part II. Preferred implant neck color to improve soft tissue esthetics. Clin. Oral Impl. Res.18; 2007; 575-580

• Zetterqvist L. et al. A Prospective, Multicenter, Randomized-controlled 5 year study of Hybrid and Fully-Etched Implants for incidence of Peri-implantitis. J Periodontology 2009 Dec 23 (14pp.)

UNICITÀ E ECCELLENZA A PREZZI ACCESSIBILI

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TUTTO IN UN UNICO LUOGO

Trovate la sala diagnostica 2D ì 3D, il laboratorio centrale, 5 studi dentistici e la stanza per le terapie medical spa tutte insieme nella nuova sede della clinica in via Ilica 283 a Zagabria.

PACHETTO DI CONSULENZA

GRATUITO PER I NUOVI PAZIENTI

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